Session Index

A novel optical resonant-state with high-quality factor and ultra-sensitivity is presented, which is mainly resonant coupling of the topological interface-states and the optical cavity-modes in one-dimensional photonic systems, namely topological cavity-states (TCS). A key feature of TCS is topological protection and therefore robustness in the presence of structural imperfection. The potential applications of TCS in bio-photonic sensors have also been discussed, including ultra-sensitivity of 2000 nm/RIU and high-Q of 10^9 for detecting analyte solution. TCS in one-dimensional photonic systems not only opens new possibilities for advanced optical resonators, but also provides practical applications in ultra-sensitivity and high-Q, especially bio-photonic sensors.

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Heren, we synthesized polyaniline-containing galactosylated Ag aggregation-structure nanoparticles (Ag@PGlyco-PSMA ANPs) via an in-situ polymerization of ortho-nitrophenyl-β-galactopyranoside and reduction of Ag ions. The addition of poly(styrene-alt-maleic acid) sodium salt solution (PSMA) hindered the precipitation of Ag@PGlyco-PSMA ANPs and provided exceptional bio-compatibility due to the lowering Ag ion release. Because the Ag@PGlyco-PSMA ANPs have intrinsic polyaniline-based SERS signal, we demonstrated the H2O2 sensing ability in terms of SERS signal decrease. As performing SERS mapping imaging technology, the new SERS probe allowed to screen the cancer cells with high intracellular H2O2 concentration compared with the normal cells.

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We developed a sugar carbonization reaction of o-nitrophenyl-β-D-galactopyranoside (ONPG) to fabricate glycosyl-/graphene-based nanoparticles (ONPG NPs). As hybridized with iron chlorophyll (Chl/Fe) photosensitizers, the ONPG-Chl/Fe NPs could perform PDT and CDT to kill cancer cells. Because ONPG-Chl/Fe exposed saccharide molecules on the particle surface, enabling to recognize the lectin receptors at the macrophage, the following downstream biologic effects induced M0 macrophage polarization to M1 phenotype. Combined with PDT and CDT to cancer cells, we demonstrated that reprogramming in the generation of M1-type macrophage was improved for the benefit integration of the immunotherapy after sugar-mediated phototherapy.

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This study simulates the pinhole tunneling effect of the single-photon emission microscope (SPEM) and establishes the imaging models from the simulated point response functions. The models include the flux model, width model and principal angle model. The imaging system matrix is then generated by using the established models. Subsequently, we use the ordered-subset expectation maximization algorithm (OSEM) to reconstruct 3D object images with the corresponding projected images and system matrix. The image reconstruction results validate the established pinhole tunneling model and imaging system matrix.

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In this study, we analyzed the natural photonic crystal structures comprised in Turquoise-fronted Amazon Parrot feathers. Using UV-Vis spectrophotometry, we validated that, upon pigment removal, the photonic crystal exhibited a significant enhancement in reflectance across the range of 400-900 nm wavelength, surpassing 65%. Notably, it achieved a peak reflectance of 79% at 530 nm. We replicated the photonic crystal found in Turquoise-fronted Amazon Parrot feathers to construct a model through the simulation by Finite-Difference Time-Domain (FDTD) method. Our verification process confirmed that this structure possesses a remarkably high reflectance of 95% within the wavelength of 510 nm to 570 nm.

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This study created Au@2ATP@ONPG nanoparticles using ONPG and 2ATP, capable of SERS tracking, targeting cancer cells, and stimulating macrophage polarization for immune activation. Sugar-based ONPG polymerization on the gold surface forms a conductive PANI backbone and enhances Raman scattering (SERS) on the gold core, allowing particle concentration detection within cancer cells through SERS intensity. Thus, Au@2ATP@ONPG carried the photosensitizer Ce6, resulting in Au@2ATP@ONPG@Ce6. This biophotonic nanoparticle design could induce PDT effects and transform M2-to-M1 macrophages, prompted by PDT-triggered ROS production upon macrophage binding. This enhanced immune response against cancer cells led to observed PDT-elicited immunotherapy effects.

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Spontaneously hypertensive rat (SHR) is a well-known animal model of human essential hypertension and the most used model of hypertension and cardiovascular disease so far [1]. We investigated that treatment of hypertensive rats with intravascular laser irradiation of blood (ILIB) [2] improves blood pressure through molecular mechanisms of central cardiovascular regulation. We observed that the administration of 10mW ILIB to SHR rats can reduce the blood pressure of SHR rats, but increase the blood pressure of WKY rats. Next-generation sequencing to analyze the nucleus tractus solitarii found that differentially expressed genes were significantly different between SHR and WKY rats.

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Extracellular viscosity plays a significant role as a biophysical stimulus, varying within the microenvironment of different tumor types. In this study, we increased the viscosity of the cell culture medium by supplementing it with 0.8% Methylcellulose (MC), raising its viscosity from 0.98 cp to 68.14 cp. We demonstrated how extracellular viscosity regulates cell biomechanical and biochemical properties, including cell spreading, actin and focal adhesion formation, and cell junctions. This, in turn, enhances tumor spheroid formation and promotes the invasion capability of cancer cells from tumor spheroids into surrounding 3D collagen matrices.

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Intravascular laser irradiation of blood (ILIB) is a therapeutic technique that was initially developed for cardiovascular diseases and represents a novel application of lasers in medicine [1]. We aim to investigate these changes and determine the molecular mechanisms involved in post-stroke rehabilitation patients. Our demonstrated differential gene expression before and after ILIB treatment in ischemic stroke patients. These genes were significantly enriched in pathways related to TNF signaling, IL-17 signaling, cancer misregulation, and osteoclast differentiation. Furthermore, gene ontology analyses revealed significant enrichment in biological processes, cellular components, and molecular functions related to immune response, hemopoiesis, and oxidoreductase activity, among others.

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Cancer cells often re-program the metabolism to promote their growth and strengthen resistance to chemotherapies. The formation of lipid droplets in cancer cells is one of the indications of this alternation. Therefore, to identify the quantity and type of lipid in the lipid droplets of cancer cells is critical. In this work, the dark-field microscopy is combined with Raman spectroscopy to identify the lipid droplets in liver cancer cells. The primitive results show that the Raman identification may be used to clarify the relationship between external stimulus and lipid droplets.

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